Elston Neil D'Souza, Jonathan Talbot-Martin, Daniel G. MacArthur and Nicola Whiffin

The 5’ UTR of a given gene includes elements that have the potential regulate mRNA translation such as uORFs. Variants in 5’ UTRs can modify or entirely disrupt translation through various different mechanisms (such as new creating uAUG that can create uORFs) or alternatively perturb existing ORFs. VuTR provides an open and easy-to-use interface to visualise high-impact variants within 5' UTRs within population datasets (gnomAD version 3.1.2) and ClinVar on MANE transcripts. Users are also able to select their visualise 5' UTR architechure and input their 5' UTR Variant SNV and visualise their UTR consequence through the UTR Annotator Plugin in our application.